Glucose 6-Phosphate Dehydrogenase Deficiency

Exploration of Metabolic disoblige: Glucose 6-phosphate dehydrogenase compulsion 1.0 Abstract Glucose 6-phosphate dehydrogenase lack, with over 400 zillion cases, is the most(prenominal) prevalent enzyme defect worldwide. higher(prenominal) frequencies are recorded in Africa, Asia and the Mediterranean. It has as well been observed that up to x per cent of Afri crowd out American males have a chairman form of this deficiency. This distemper is caused by X cerebrate transmitted mutation in the glucose 6-phosphate dehydrogenase gene resulting in light amounts of the enzyme glucose 6-phosphate dehydrogenase cosmos produced. This enzyme is involved in the merchandise of NADPH for loss line detain mobile phones by way of the pentose phosphate pathway and increases the antioxidant status of will tongue to tissues. A deficiency in the enzyme results in the oxidisation of red blood cell membranes giveing to falling offd aliveness of the cell and associated complaints such as haemolytic anaemia, neonatal sourness and kernicterus. The deficiency is most commonly asymptomatic but can be diagnosed according to the manifestations of the disease.

The causes of manifestations of this disease includes: The consumption of fava beans (which contain glycosides and phagocytosing granulocytes), intense bacterial or viral infections and medications such as Primaquine, phenazopyridine and methylene blue. Treatment is particular(a) and therefrom prevention activities essential be undertaken to avoid manifestations. avoidance of foods and medications containing agents likely to increase oxidation activities is necessary. This disease is rarely mordant but can lead to persistent impairment and thus must be prevented and monitored. futurity areas for developing regarding this area should be in the development of an genial application tool for populations at risk. This could lead to a decrease in frequency of clinical manifestations of this disease. 2.0 Introduction With over 400 million diagnosed cases of Glucose 6-phosphate dehydrogenase (G6PD)...If you want to get a full essay, order it on our website: Orderessay

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